More than 1,000 distinguished global leaders have signed a letter addressed to UN Secretary General Ban Ki-moon urging him to begin the process of making real and effective changes to global drug policy and the war on drugs.

The letter says “Tens of millions of people, mostly poor and racial and ethnic minorities, were incarcerated, mostly for low-level and non-violent drug law violations, with little if any benefit to public security.”

And goes on to say “Humankind cannot afford a 21 st century drug policy as ineffective and counter-productive as the last century’s.  A new global response to drugs is needed, grounded in science, compassion, health and human rights.”

Those who have signed the letter are an eclectic group that include people from politics, business, science and health fields, and religious leaders, as well as the music and film industry.

The political figures include former presidents and prime ministers of Mexico, Switzerland, Nigeria and Greece, as well as presidential candidate Bernie Sanders. Those who signed from the music and acting world include DJ Khaled, Woody Harrelson, John Legend, Jane Fonda and Sting. Other interesting signs include Tom Brady, Alexander Wang and Warren Buffet.